Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders.

Leung-Wah YickChi-Ho TangOscar Ka-Fai MaJason Shing-Cheong KwanKoon Ho Chan

Published in: Journal of neuroinflammation (2020)

Our findings support that glutamate excitotoxicity and neuroinflammation play important roles in complement-independent pathophysiology during early development of NMOSD lesions, and highlight the potential of oral memantine as a therapeutic agent in NMOSD acute attacks.

Keyphrases

mouse model
liver failure
respiratory failure
traumatic brain injury
lipopolysaccharide induced
drug induced
aortic dissection
cognitive impairment
human health
cerebral ischemia
hepatitis b virus
intensive care unit
inflammatory response
blood brain barrier
extracorporeal membrane oxygenation