Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts.
Annalena WielandPamela L StrisselHannah SchorleEzgi BakirciDieter JanzenMatthias W BeckmannMarkus EcksteinPaul D DaltonReiner StrickPublished in: Cancers (2021)
This study demonstrates a significant role of the PTEN genotype and RHOB expression for durotaxis, adhesion and migration dependent on 3D. GBM and TNBC cells with PTEN loss of function have an affinity for stiff brain structures promoting metastasis. 3D microfibers represent an important tool to model brain metastasizing tumor cells, where RHO-inhibitors could play an essential role for improved therapy.
Keyphrases
- resting state
- white matter
- cell proliferation
- pi k akt
- breast cancer cells
- functional connectivity
- cell cycle arrest
- induced apoptosis
- cerebral ischemia
- signaling pathway
- high resolution
- multiple sclerosis
- dna methylation
- escherichia coli
- oxidative stress
- genome wide
- single cell
- brain injury
- mass spectrometry
- cystic fibrosis
- subarachnoid hemorrhage
- biofilm formation
- cell therapy