Fluorescent in situ hybridization has limitations in screening NRG1 gene rearrangements.

Xiaomei ZhangLin LiFuping GaoBinbin LiuJing LiShuang RenShuangshuang PengWei QiuXiaohong PuQing Ye

Published in: Diagnostic pathology (2024)

Considering the high cost of NGS, FISH remains a useful method for screening NRG1 fusions in various types of tumors. This study provides valuable insights into the molecular mechanisms of NRG1 fusion and identifies potential treatment targets for patients suffering from this disease.

Keyphrases

end stage renal disease
genome wide
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
copy number
gene expression
risk assessment
patient reported outcomes
combination therapy