Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway.
Hongyan LiaoJiagui HuangJie LiuHuimin ZhuYue ChenXuemei LiJun WenQin YangPublished in: Molecular biology reports (2023)
These findings suggested that Sirt1 may regulate microglial activation and inflammation by targeting the Shh/Gli-1 signaling pathway following OGD/R injury. Schematic representation of Sirt1 regulating the microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury via mediation of Shh/Gli-1 signaling pathway.
Keyphrases
- oxidative stress
- signaling pathway
- induced apoptosis
- pi k akt
- inflammatory response
- lipopolysaccharide induced
- ischemia reperfusion injury
- lps induced
- epithelial mesenchymal transition
- neuropathic pain
- blood glucose
- endoplasmic reticulum stress
- metabolic syndrome
- spinal cord injury
- blood pressure
- spinal cord
- depressive symptoms
- neural network