Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis.
Bob SmitYvo M SmuldersEtto C EringaHeleen M Oudemans-van StraatenArmand R J GirbesKimberley E WeverCarlijn R HooijmansAngelique M E Spoelstra-de ManPublished in: Critical care (London, England) (2018)
The effect of hyperoxia on vascular tone is substantially higher in vivo than ex vivo. The magnitude of the constriction is most pronounced in vessels ~ 15-25 μm in diameter and is proportional to the level of hyperoxia. Relatively increased constriction was seen in muscle vasculature, while reduced constriction was seen in the skin and intestines.