Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease.
Femke Christina Ching-Chuan van Rhijn-BrouwerBas W M van BalkomDiana A PapazovaDiënty H M HazenbrinkAnke J MeijerIsaac BreteVidalmar BricenoArjan D van ZuilenRaechel J TooropJoost O FledderusCoen D A StehouwerMarianne Christina VerhaarPublished in: Stem cells international (2019)
Our results indicate that MSCs have an intrinsic capacity to produce proangiogenic paracrine factors, including EVs, which is not affected by donor health status regarding CKD. This suggests that autologous MSC-based therapy is a viable option in CKD.