Free heme induces cognitive impairment, and the underlying mechanism may involve neuronal apoptosis and microglial inflammation via the TLR4/MyD88/NF-κB signaling pathway. HPX may have potential therapeutic effects. Video Abstract.
Keyphrases
- cognitive impairment
- signaling pathway
- toll like receptor
- inflammatory response
- lps induced
- pi k akt
- lipopolysaccharide induced
- oxidative stress
- nuclear factor
- cell cycle arrest
- epithelial mesenchymal transition
- induced apoptosis
- immune response
- neuropathic pain
- endoplasmic reticulum stress
- cell death
- cell proliferation
- cerebral ischemia
- spinal cord
- spinal cord injury
- subarachnoid hemorrhage