Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis.
Mingyao YangFrancisco DiazAna Rita T KrauseYuguo LeiWan-Sheng LiuPublished in: Cell & bioscience (2024)
Data from sKO and dKO mice unveil a synergistic interaction via the RA signaling pathway between Pramex1 and Pramel1 genes during gametogenesis. This discovery sets the stage for investigating interactions among other members within the Prame family, advancing our understanding of multi-copy gene families involved in germ cell formation and function.
Keyphrases
- germ cell
- signaling pathway
- rheumatoid arthritis
- genome wide
- genome wide identification
- cancer therapy
- disease activity
- small molecule
- ankylosing spondylitis
- pi k akt
- copy number
- electronic health record
- genome wide analysis
- high fat diet induced
- epithelial mesenchymal transition
- dna methylation
- high throughput
- interstitial lung disease
- systemic lupus erythematosus
- transcription factor
- induced apoptosis
- drug delivery
- insulin resistance
- metabolic syndrome
- oxidative stress
- gene expression
- cell proliferation
- artificial intelligence