Login / Signup

Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles.

Yuxiu LiKuai WangYuanyuan PingYifan WangWangqing Kong
Published in: Organic letters (2018)
The first nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction for the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers is reported. A wide range of electrophiles, such as aryl iodides, bromides, triflates, and chlorides, are all compatible with the reaction conditions. Moreover, cheap aryl esters, which undergo catalytic C-O bond cleavage, could also be employed as electrophiles. The approach shows good yields and broad scope, complementing a more practical and sustainable alternative to the conventional palladium-based analogues.
Keyphrases
  • room temperature
  • reduced graphene oxide
  • electron transfer
  • ionic liquid
  • oxide nanoparticles
  • carbon nanotubes
  • gold nanoparticles
  • dna binding
  • crystal structure
  • solid state