IL-33/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy.
Yan-Ran ShengWen-Ting HuChun-Yan WeiLing-Li TangYu-Kai LiuYu-Yin LiuJian-Ping QiuDa-Jin LiXiao-Yong ZhuPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
This study indicates that IL-33 secreted by dMφs promotes M2 bias at the feto-maternal interface, and as a result, RSA might attribute to the disturbance of IL-33/ST2 axis and the enhancement of efferocytosis of dMφs subsequently.