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Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy.

Akshansh SharmaArun KumarSadanand PandeyDeepak Kumar
Published in: RSC medicinal chemistry (2022)
Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm. A Tim-3 receptor is an immune checkpoint that prevents overactivation. Its malfunction is related to autoimmune diseases and is mediated by phosphorylation of Tim-3 and other ligands. Photophosphatidylserine (phoPS) is a photoswitchable instrument that regulates NK cells through Tim-3. PS is bound to multiple receptors; therefore it can be utilised against cancer, infectious disorders, and autoimmune diseases, though more in vitro and in vivo research studies are needed.
Keyphrases
  • nk cells
  • papillary thyroid
  • multiple sclerosis
  • squamous cell
  • mouse model
  • squamous cell carcinoma
  • patient reported outcomes
  • case control
  • lymph node metastasis
  • drug induced