Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus .

Thaila Fernanda Dos ReisCamila DiehlCamila Figueiredo PinzanPatrícia Alves de CastroGustavo Henrique Goldman

Published in: Microbiology spectrum (2024)

. BRI is a small molecule host defense peptide mimetic that has previously exhibited broad-spectrum immunomodulatory/anti-inflammatory activity against bacteria and viruses. We propose the combination of BRI and IBX as a new antifungal combinatorial treatment against aspergillosis.

Keyphrases

small molecule
endothelial cells
candida albicans
innate immune
induced pluripotent stem cells
combination therapy
replacement therapy
genetic diversity