Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder.
Toshiharu KamishikiryoGo OkadaEri ItaiYoshikazu MasudaSatoshi YokoyamaMasahiro TakamuraManabu FuchikamiAtsuo YoshinoKazuaki MawatariShusuke NumataAkira TakahashiTetsuro OhmoriYasumasa OkamotoPublished in: Psychiatry and clinical neurosciences (2022)
Decreased resting-state regional activity of the left DLPFC and decreased plasma kynurenine levels may predict treatment response to escitalopram, suggesting that it may be involved in the pathophysiology of major depressive disorder in response to escitalopram treatment.