FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC.
Thomas E BickettMichael William KnitzLaurel B DarraghShilpa BhatiaBenjamin Van CourtJacob GadwaShiv BhuvaneMiles PiperDiemmy NguyenHua TuLaurel L LenzEric T ClambeyKevin C BarrySana D KaramPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These findings highlight the complexity of using radio-immunotherapies to activate NK cells within the tumor microenvironment, and the importance of NK cells in activating dendritic cells for increased tumor surveillance.