Paraneoplastic myopathy in pancreatic cancer: a case report and literature review.
Jessica Joanne PadniewskiElizabeth NelsonIstiaq MianAndrew LaczniakSamuel IvesRawad NasrPublished in: Journal of community hospital internal medicine perspectives (2021)
Dermatomyositis (DM) and polymyositis (PM) are both immune-mediated inflammatory myopathies known to occur in paraneoplastic syndromes associated with a new diagnosis of malignancy, most commonly breast, ovarian, lung, pancreatic, stomach, colorectal, and Non-Hodgkin's lymphoma1 in DM and breast, lung, bladder cancer, and Non-Hodgkin's lymphoma in PM. 2,3,4 While inflammatory markers such as creatine kinase (CK) may be elevated with either DM or PM, marked elevation is rare. Herein, we report a case of newly diagnosed pancreatic cancer presenting with inflammatory myopathy and marked CK elevation. We review the frequency of PM as a paraneoplastic syndrome, the association with marked CK elevation, and the association with pancreatic cancer.
Keyphrases
- particulate matter
- air pollution
- protein kinase
- polycyclic aromatic hydrocarbons
- heavy metals
- newly diagnosed
- diffuse large b cell lymphoma
- water soluble
- interstitial lung disease
- oxidative stress
- hodgkin lymphoma
- glycemic control
- case report
- type diabetes
- rheumatoid arthritis
- systemic lupus erythematosus
- disease activity
- tyrosine kinase
- early onset
- skeletal muscle
- duchenne muscular dystrophy