Concomitant Resistance to Cefiderocol and Ceftazidime/Avibactam in Two Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Lung Transplant Patients.
Greta BellinzonaCristina MerlaMarta CorbellaElizabeth Nagy IskandarElena SeminariAngela Di MatteoStefano GaiarsaGreta PetazzoniDavide SasseraFausto BaldantiAurora PiazzaPatrizia CambieriPublished in: Microbial drug resistance (Larchmont, N.Y.) (2023)
In this study, we present two cases of Klebsiella pneumoniae , one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.
Keyphrases
- klebsiella pneumoniae
- gram negative
- multidrug resistant
- escherichia coli
- drug resistant
- end stage renal disease
- acinetobacter baumannii
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- extracorporeal membrane oxygenation
- cystic fibrosis
- patient reported outcomes
- pseudomonas aeruginosa
- acute care