Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC-QTOF-MS.
Andrew S DavisonBrendan P NormanGordon A RossAndrew T HughesMilad KhedrAnna M MilanJames A GallagherLakshminarayan R RanganathPublished in: JIMD reports (2019)
Nitisinone therapy has a significant impact on several metabolites beyond the tyrosine metabolic pathway, several of which appear to be related to the redox state of the cell.