Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC-QTOF-MS.

Andrew S DavisonBrendan P NormanGordon A RossAndrew T HughesMilad KhedrAnna M MilanJames A GallagherLakshminarayan R Ranganath

Published in: JIMD reports (2019)

Nitisinone therapy has a significant impact on several metabolites beyond the tyrosine metabolic pathway, several of which appear to be related to the redox state of the cell.

Keyphrases

ms ms
mass spectrometry
cell therapy
single cell
multiple sclerosis
stem cells
simultaneous determination
bone marrow
combination therapy
smoking cessation