CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway.

Jiewen ChenQingji XuDan LiuXun LiMingyan GuoXuehui ChenJianyou LiaoRong LeiWende LiHongyan HuangPhei Er SawErwei SongXiyun YanYan Nie

Published in: Cancer communications (London, England) (2023)

These findings suggested that CD146 served as an efficacious marker for predicting PT malignant progression and showed promise as a prognosis marker and treatment target of breast malignant PTs. The study further unveiled the essential role of the CD146-DCBLD2/PI3K/AKT axis in the malignant progression of PTs.

Keyphrases

signaling pathway
pi k akt
cell proliferation
nk cells
cell cycle arrest
machine learning
big data
cell death
artificial intelligence