Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.
Ashley O RoenLars PetersGilles WandelerMarc van der ValkRobert ZangerleHuldrych F GünthardFerdinand WitCristina MussiniStéphane De WitAntonella d'Arminio MonforteJörg Janne VehreschildAntonella CastagnaNadine JaschinskiVani VannappagariLinda ChenJoan TalladaJohn C'marAmanda MocroftLene RyomPublished in: Open forum infectious diseases (2024)
cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk.