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12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.

Xiaofang WangLu GaoLili XiaoLulu YangWenshu LiGangqiong LiuLinlin ChenJin-Ying Zhang
Published in: Journal of diabetes investigation (2018)
The lipoxygenases metabolite, 12(S)-HETE, can impair vascular endothelial permeability by altering adherens junction phosphorylation levels, and affecting the binding and dissociation of its components in high-glucose conditions.
Keyphrases
  • high glucose
  • endothelial cells
  • protein kinase
  • dna binding
  • transcription factor
  • diabetic rats