RANKL is associated with persistent primary teeth and delayed permanent tooth emergence.
Juliana AridThaís Aparecida XavierRaquel Assed Bezerra da SilvaAndiara De RossiLea Assed Bezerra da SilvaAlexandra Mussolino de QueirozRodrigo GaloLivia Azeredo Alves AntunesMarcelo José Barbosa SilvaLeonardo Dos Santos AntunesZerrin AbbasogluPaulo Nelson FilhoErika Calvano KüchlerSandra Yasuyo Fukada AlvesPublished in: International journal of paediatric dentistry (2019)
Data suggest that the polymorphism rs9594738 in RANKL is associated with delayed permanent tooth emergence. Moreover, reduced relative gene expression of RANKL in periapical tissue is associated with persistent primary teeth.