Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress.
Joshua JenkinsJ MantellC NealA GholiniaPaul VerkadeAngela H NobbsB SuPublished in: Nature communications (2020)
Some insects, such as dragonflies, have evolved nanoprotrusions on their wings that rupture bacteria on contact. This has inspired the design of antibacterial implant surfaces with insect-wing mimetic nanopillars made of synthetic materials. Here, we characterise the physiological and morphological effects of mimetic titanium nanopillars on bacteria. The nanopillars induce deformation and penetration of the Gram-positive and Gram-negative bacterial cell envelope, but do not rupture or lyse bacteria. They can also inhibit bacterial cell division, and trigger production of reactive oxygen species and increased abundance of oxidative stress proteins. Our results indicate that nanopillars' antibacterial activities may be mediated by oxidative stress, and do not necessarily require bacterial lysis.
Keyphrases
- oxidative stress
- gram negative
- single cell
- multidrug resistant
- cell therapy
- reactive oxygen species
- dna damage
- ischemia reperfusion injury
- stem cells
- silver nanoparticles
- diabetic rats
- magnetic resonance imaging
- induced apoptosis
- computed tomography
- anti inflammatory
- escherichia coli
- magnetic resonance
- biofilm formation
- zika virus
- signaling pathway
- bone marrow
- essential oil
- soft tissue