Anti-migraine Calcitonin Gene-Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice.
Inge A MulderMei LiTessa de VriesTao QinTakeshi YanagisawaKazutaka SugimotoAntoon van den BogaerdtA H Jan DanserMarieke J H WermerArn M J M van den MaagdenbergAntoinette MaassenVanDenBrinkMichel D FerrariCenk AyataPublished in: Annals of neurology (2020)
Gepants worsened ischemic stroke in mice via collateral dysfunction. CGRP pathway blockers might thus aggravate coincidental cerebral ischemic events. The cerebrovascular safety of these agents must therefore be better delineated, especially in patients at increased risk of ischemic events or on prophylactic CGRP inhibition. ANN NEUROL 2020;88:771-784.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- high fat diet induced
- ischemia reperfusion injury
- brain injury
- oxidative stress
- blood brain barrier
- genome wide
- type diabetes
- copy number
- insulin resistance
- angiotensin converting enzyme
- dna methylation
- neural network
- skeletal muscle
- transcription factor
- genome wide identification