TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma.
Paolo Boscolo RizzoSilvia GiuncoEnrica RampazzoMartina BruttiGiacomo SpinatoAnna MenegaldoMarco StellinMonica MantovaniLuigia BandolinMarco RossiAnnarosa Del MistroGiancarlo TirelliAngelo Paolo Dei TosAngela GuerrieroMonia NieroMaria Cristina Da MostoJerry PoleselAnita De RossiPublished in: Journal of cancer research and clinical oncology (2020)
TERT promoter mutations are most likely a late event in tumor development, occurring in a context of critically short telomeres, mostly in patients with oral cavity SCC. TERT levels, but not TERT promoter mutational status impact clinical outcome.