Tailoring Biomaterials Ameliorate Inflammatory Bone Loss.
Shi ChengKong-Huai WangLu ZhouZhi-Jun SunLu ZhangPublished in: Advanced healthcare materials (2024)
Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease, and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, the advances of biomaterials for ameliorating inflammatory bone loss are listed. Additionally, the advantages and disadvantages of various biomaterials-mediated strategies are summarized. Finally, the challenges and perspectives of biomaterials are analyzed. This review aims to provide new possibilities for developing more advanced biomaterials toward inflammatory bone loss.
Keyphrases
- bone loss
- oxidative stress
- tissue engineering
- bone regeneration
- chronic obstructive pulmonary disease
- rheumatoid arthritis
- end stage renal disease
- celiac disease
- chronic kidney disease
- physical activity
- newly diagnosed
- ejection fraction
- young adults
- cystic fibrosis
- systemic sclerosis
- systemic lupus erythematosus
- body composition
- idiopathic pulmonary fibrosis