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Gene fusion involving the insulin-like growth factor 1 receptor in an ALK-negative inflammatory myofibroblastic tumour.

Giuseppe PiarulliFlorian PulsBo WängbergHenrik FagmanMagnus HanssonJenny NilssonElsa ArbajianFredrik Mertens
Published in: Histopathology (2019)
We found a novel fusion gene - FN1-IGF1R. The FN1 gene, encoding ?bronectin, is thought to provide a strong promoter activity for the kinase domain of the RTK insulin-like growth factor 1 receptor, a mechanism similar to previously described RTK fusions in IMT.
Keyphrases
  • genome wide
  • copy number
  • genome wide identification
  • dna methylation
  • gene expression
  • binding protein
  • oxidative stress
  • transcription factor
  • advanced non small cell lung cancer