Gene fusion involving the insulin-like growth factor 1 receptor in an ALK-negative inflammatory myofibroblastic tumour.
Giuseppe PiarulliFlorian PulsBo WängbergHenrik FagmanMagnus HanssonJenny NilssonElsa ArbajianFredrik MertensPublished in: Histopathology (2019)
We found a novel fusion gene - FN1-IGF1R. The FN1 gene, encoding ?bronectin, is thought to provide a strong promoter activity for the kinase domain of the RTK insulin-like growth factor 1 receptor, a mechanism similar to previously described RTK fusions in IMT.