The Effect of Standard Versus Longer Intestinal Bypass on GLP-1 Regulation and Glucose Metabolism in Patients With Type 2 Diabetes Undergoing Roux-en-Y Gastric Bypass: The Long-Limb Study.
Alexander Dimitri MirasAnna KamockaBelén Pérez-PevidaSanjay PurkayasthaKrishna MoorthyAmeet PatelHarvinder ChahalGary S FrostPaul BassettLidia Castagnetto-GisseyLucy CoppinNicola JacksonAnne Margot UmplebyStephen Robert BloomTricia Mei-Mei TanAhmed Rashid AhmedFrancesco RubinoPublished in: Diabetes care (2020)
The findings of this study demonstrate that lengthening of the intestinal bypass in RYGB does not affect GLP-1 secretion. Thus, the characteristic enhancement of GLP-1 response after RYGB might not depend on delivery of nutrients to more distal intestinal segments.