Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions.
Ursula Castro de OliveiraMilton Yutaka NishiyamaMaria Beatriz Viana Dos SantosAndria de Paula Santos-da-SilvaHipócrates de Menezes ChalkidisAndreia Souza-ImbergDenise Maria CandidoNorma YamanouyeValquíria Abrão Coronado DorceInácio de Loiola Meirelles Junqueira-de-AzevedoPublished in: PloS one (2018)
The present work shows that the venom composition of these two allopatric species of Tityus are considerably similar in terms of the major classes of proteins produced and secreted, although their individual toxin sequences are considerably divergent. These differences at amino acid level may reflect in different epitopes for the same protein classes in each species, explaining the basis for the poor recognition of T. obscurus venom by the antiserum raised against other species.