CSNK2A1-mediated MAX phosphorylation upregulates HMGB1 and IL-6 expression in cholangiocarcinoma progression.

Bing Yang Jing Zhang Jiaohong Wang Wei Fan Lucía Barbier-Torres Xi Yang Monica Anne R Justo Ting Liu Yongheng Chen Justin A Steggerda Komal Ramani Shelly C Lu Heping Yang

Published in: Hepatology communications (2023)

C-MYC-MAX and β-catenin-MAX binding to E-box site or β-catenin-MAX bound to TCFs/LEF1 enhanced HMGB1 or IL-6 promoter activities, respectively. IL-6 and HMGB1 secreted by hepatocytes, HSCs, and KCs exert paracrine effects on cholangiocytes to promote cell growth, migration, and invasion and lead to the progression of cholangiocarcinogenesis. CX-4945 provides perspectives on therapeutic strategies to attenuate progression from atypical cystic hyperplasia to cholangiocarcinogenesis.

Keyphrases

cell proliferation
transcription factor
epithelial mesenchymal transition
gene expression
binding protein
dna methylation
signaling pathway