Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation.
Shweta Kishor SonawaneVladimir N UverskySubashchandrabose ChinnathambiPublished in: Cell communication and signaling : CCS (2021)
In conclusion, Baicalein inhibits aggregation of hTau40 by enhancing the formation of SDS-stable oligomers and preventing fibril formation. Baicalein-induced oligomers do not affect the viability of the neuroblastoma cells. Therefore, Baicalein can be considered as a lead molecule against Tau pathology in AD. Video Abstract.