Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms.

Tri NguyenRebecca ParkerYu ZhangElisa HawkinsMaciej KmieciakWilliam CraunSteven Grant

Published in: BMC cancer (2018)

These findings indicate that HHT and bortezomib cooperate to kill DLBCL and MCL cells through a process involving MCL-1 down-regulation, NOXA up-regulation, and BAK activation. They also suggest that a strategy combining HHT with bortezomib warrants attention in DLBCL and MCL.

Keyphrases

induced apoptosis
multiple myeloma
cell cycle arrest
diffuse large b cell lymphoma
newly diagnosed
signaling pathway
cell death
working memory
pi k akt