Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension.

Lizhe GuoGang QinYanan CaoYue YangSisi DaiLu WangE Wang

Published in: Journal of inflammation research (2021)

Selective inhibition of NLRP3 pathway interfered the interaction between hypertrophic cardiomyocytes and macrophages in the initial stage of inflammation and maintained the immune microenvironment balance, eventually contributing to attenuation of LPS-induced acute heart failure in PAH rats.

Keyphrases

pulmonary arterial hypertension
lps induced
acute heart failure
inflammatory response
stem cells
pulmonary artery
pulmonary hypertension
heart failure
oxidative stress
liver failure
respiratory failure
nlrp inflammasome
coronary artery
aortic dissection
extracorporeal membrane oxygenation