Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review.

Leontien C M KremerSimone J VerkleijElizabeth A M FeijenAnnelies M C Mavinkurve-GroothuisMilanthy S PourierKaisa YlänenWim J E TissingMarloes LouwerensMarry M van den HeuvelEline van Dulmen-den BroederAndrica C H de VriesCecile M RonckersHeleen J H van der PalLivia KapustaJacqueline LoonenLouise BellersenYigal M PintoLeontien C M KremerWouter E M Kok

Published in: Heart (British Cardiac Society) (2018)

In individual studies, the diagnostic value of NT-proBNP for detection of LV dysfunction in CCS is limited. Troponins have no role in detecting late-onset LV dysfunction with cut-off values as low as 0.01 ng/mL. Further study on optimal NT-proBNP cut-off values for rule out or rule in of LV dysfunction is warranted.

Keyphrases

late onset
oxidative stress
early onset
heart failure
left ventricular
childhood cancer
real time pcr
label free
catheter ablation