The putative lithium-mimetic ebselen reduces impulsivity in rodent models.

Chris Barkus Jacqueline-Marie M FerlandWendy K AdamsGrant C ChurchillPhilip J CowenDavid M BannermanRobert D RogersCatharine A WinstanleyTrevor Sharp

Published in: Journal of psychopharmacology (Oxford, England) (2018)

These findings suggest that ebselen preferentially reduces motor impulsivity over choice impulsivity, and that inhibition of 5-HT2A receptor function is a contributing mechanism. Collectively, these data support the repurposing of ebselen as an anti-impulsive treatment and fast-tracking to clinical trials in patient groups characterised by poor impulse control.

Keyphrases

obsessive compulsive disorder
clinical trial
borderline personality disorder
case report
electronic health record
big data
artificial intelligence
deep brain stimulation
decision making
deep learning
replacement therapy