CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx.

Viacheslav M MorozovSerena GiovinazziAlexander M Ishov

Published in: Epigenetics & chromatin (2017)

The demonstrated roles of CENP-B and SUMO-2 in H3.3 loading reveal a novel mechanism controlling chromatin maintenance and genome stability. Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin.

Keyphrases

genome wide
gene expression
dna methylation
dna damage
transcription factor
circulating tumor
cell free
single molecule
single cell
heat shock protein
oxidative stress
amino acid
binding protein
nucleic acid
heat shock