Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS.

Tian LanPing FangXuemei YeXia LanRen-Ai Xu

Published in: Pharmaceutical biology (2022)

Our study indicated that shikonin could inhibit ambrisentan metabolism. Further studies need to be carried out to verify whether similar interaction truly apply in humans and whether this interaction has clinical significance.

Keyphrases

ms ms
emergency department
mass spectrometry
adverse drug
electronic health record