Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques.
Uijin KimDong-Sung LeePublished in: Molecules and cells (2023)
The genome is almost identical in all the cells of the body. However, the functions and morphologies of each cell are different, and the factors that determine them are the genes and proteins expressed in the cells. Over the past decades, studies on epigenetic information, such as DNA methylation, histone modifications, chromatin accessibility, and chromatin conformation have shown that these properties play a fundamental role in gene regulation. Furthermore, various diseases such as cancer have been found to be associated with epigenetic mechanisms. In this study, we summarized the biological properties of epigenetics and single-cell epigenomic profiling techniques, and discussed future challenges in the field of epigenetics.
Keyphrases
- dna methylation
- genome wide
- single cell
- gene expression
- induced apoptosis
- rna seq
- cell cycle arrest
- dna damage
- endoplasmic reticulum stress
- high throughput
- transcription factor
- copy number
- papillary thyroid
- oxidative stress
- cell death
- squamous cell carcinoma
- current status
- bone marrow
- young adults
- signaling pathway
- lymph node metastasis
- health information
- pi k akt
- social media