Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.

Sree RayavarapuWilliam ColeyJack H Van der MeulenErdinc CakirKathyayini TappetaTravis B KinderBlythe C DillinghamKristy J BrownYetrib HathoutKanneboyina Nagaraju

Published in: Arthritis and rheumatism (2014)

Our findings indicate that ER stress activates downstream UPPs and contributes to muscle degeneration and that UCHL-1 is a potential biomarker for disease progression. UPP inhibition offers a potential therapeutic strategy for myositis.

Keyphrases

mouse model
skeletal muscle
late onset
myasthenia gravis
oxidative stress
interstitial lung disease
small molecule
human health
muscular dystrophy
climate change
idiopathic pulmonary fibrosis
duchenne muscular dystrophy