Short-term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries.

Maria JelinicChen Huei LeoSarah A MarshallSevvandi N SenadheeraLaura J ParryMarianne Tare

Published in: Microcirculation (New York, N.Y. : 1994) (2018)

In mesenteric arteries, 48-hours sRLX treatment upregulates the role of NO in the regulation of myogenic tone by enhancing eNOS dimerization, without altering overall myogenic tone or vascular remodeling.

Keyphrases

skeletal muscle
low dose
oxidative stress
endothelial cells
nitric oxide synthase
combination therapy
smoking cessation