Short-term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries.
Maria JelinicChen Huei LeoSarah A MarshallSevvandi N SenadheeraLaura J ParryMarianne TarePublished in: Microcirculation (New York, N.Y. : 1994) (2018)
In mesenteric arteries, 48-hours sRLX treatment upregulates the role of NO in the regulation of myogenic tone by enhancing eNOS dimerization, without altering overall myogenic tone or vascular remodeling.