MIDLINE BRAIN STRUCTURES IN ADULT NIEMANN-PICK TYPE C DISEASE: A CROSS-SECTIONAL STUDY.
Mark WalterfangTsutomu TakahashiMaria A Di BiaseVanessa L CropleyDaiki SasabayashiMichio SuzukiDennis VelakoulisChristos PantelisPublished in: Acta neuropsychiatrica (2023)
Our findings suggest that adult NPC patients show some markers of early neurodevelopmental disturbance, matching findings seen in psychotic disorders. The differences in AI, but not CSP, suggest neurodevelopmental change may occur early in gestation rather than post-partum. The relationship with duration of illness suggests that there may be atrophy over time in these structures, consistent with prior analyses of grey matter regions in NPC.
Keyphrases
- end stage renal disease
- white matter
- ejection fraction
- high resolution
- prognostic factors
- physical activity
- bipolar disorder
- peritoneal dialysis
- preterm infants
- artificial intelligence
- resting state
- risk factors
- young adults
- multiple sclerosis
- functional connectivity
- machine learning
- patient reported outcomes
- congenital heart disease
- mass spectrometry
- blood brain barrier
- deep learning