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Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria.

Ming YangChunye ZhangMichael Z ZhangShuping Zhang
Published in: BMC microbiology (2018)
An integrated design approach can be used to develop short and potent antimicrobial peptides, such as CAMP-A and CAMP-B. The advantageous characteristics, including structural simplicity, resistance to salts and proteases, potent antimicrobial activity, rapid membrane attacking mode, and moderate therapeutic index, suggest that CAMP-A and CAMP-B are excellent candidates for development as therapeutic agents against multidrug-resistant P. aeruginosa and methicillin-resistant staphylococci.
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