MicroRNA-27a Suppresses the Toxic Action of Mepivacaine on Breast Cancer Cells via Inositol-Requiring Enzyme 1-TNF Receptor-Associated Factor 2.
WenHong FuXiaoLing HuGengZhang LiSongTao LiuPublished in: Contrast media & molecular imaging (2023)
Elevated miR-27a in MCF-7 of BCC lineage was effective in reducing the toxic effects of mepivacaine on cells and enhancing cell progression. This mechanism is thought to be related to the activation of the IRE1-TRAF2 signaling pathway in BCC. The findings may provide a theoretical basis for targeted treatment of BC in clinical practice.
Keyphrases
- breast cancer cells
- signaling pathway
- induced apoptosis
- clinical practice
- single cell
- endoplasmic reticulum stress
- cell proliferation
- pi k akt
- cell cycle arrest
- long non coding rna
- rheumatoid arthritis
- epithelial mesenchymal transition
- long noncoding rna
- oxidative stress
- cancer therapy
- mesenchymal stem cells
- cell death
- drug delivery