miR-10b-5p rescues leaky gut linked with gastrointestinal dysmotility and diabetes.
Hannah ZoggRajan SinghSe Eun HaZhuqing WangByungchang JinMariah HaMirabel DafinoneTylar BatalonNicholas HobergSandra PoudrierLinda NguyenWei YanBrian T LaydenLara R DugasKenton M SandersSeungil RoPublished in: United European gastroenterology journal (2023)
Our study uncovered a potential pathophysiologic mechanism of gut barrier dysfunction that links both the diabetes and gut dysmotility phenotypes in mice lacking miR-10b-5p. Treatment with a miR-10b-5p mimic reversed the leaky gut, diabetic, and gut dysmotility phenotypes, highlighting the translational potential of the miR-10b-5p mimic.