Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF.

Joachim GreilbergerKatharina ErlbacherPhilipp StieglerReinhold WintersteigerRalf Herwig

Published in: Current issues in molecular biology (2023)

CPs may serve as potential markers for distinguishing between cancer cells regulated by RONS. The combination of aKG + 5-HMF showed induced cell death in high-RONS-generating cancer cells compared to low-RONS-generating cancer cells.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
high glucose
diabetic rats
oxidative stress
endoplasmic reticulum stress
pi k akt
human health