Central and peripheral α-synuclein in Parkinson disease detected by seed amplification assay.

Lana M ChahineThomas G BeachCharles H AdlerMonica HepkerAnumantha G KanthasamyScott AppelSandra PritzkowMichelle PinhoSherri MosovskyGeidy E SerranoChristopher CoffeyMichael C BrummLuis M A OliveiraJamie EberlingBrit Mollenhauernull null

Published in: Annals of clinical and translational neurology (2023)

α-synuclein seed amplification assay (cerebrospinal fluid>submandibular gland) had higher sensitivity and specificity compared to total α-synuclein measures, and within-subject relationships of central and peripheral α-synuclein measures emerged.

Keyphrases

parkinson disease
cerebrospinal fluid
deep brain stimulation
high throughput
nucleic acid
chemotherapy induced