Alpha to Omicron: Disease Severity and Clinical Outcomes of Major SARS-CoV-2 Variants.
Frank P EsperThamali M AdhikariZheng Jin TuYu Wei ChengKim El-HaddadDaniel H FarkasDavid BoslerDaniel D RhoadsGary W ProcopJennifer S KoLara JehiJing LiBrian P RubinPublished in: The Journal of infectious diseases (2022)
Disease severity associated with alpha, gamma, and delta variants is comparable while omicron infections are significantly less severe. Breakthrough disease is significantly more common in patients with omicron infection.