Login / Signup

Pathology and genomics of pediatric melanoma: A critical reexamination and new insights.

Armita BahramiRaymond L Barnhill
Published in: Pediatric blood & cancer (2017)
The clinicopathologic features of pediatric melanoma are distinct from those of the adult counterpart. For example, most childhood melanomas exhibit a uniquely favorable biologic behavior, save for those arising in large/giant congenital nevi. Recent studies suggest that the characteristically favorable biologic behavior of childhood melanoma may be related to extreme telomere shortening and dysfunction in the cancer cells. Herein, we review the genomic profiles that have been defined for the different subtypes of pediatric melanoma and particularly emphasize the potential prognostic value of telomerase reverse transcriptase alterations for these tumors.
Keyphrases
  • childhood cancer
  • skin cancer
  • rheumatoid arthritis
  • young adults
  • dna methylation
  • gene expression
  • early life
  • single cell
  • copy number
  • rare case