From GWAS to drug screening: repurposing antipsychotics for glioblastoma.
Wei-Zhi LinYen-Chun LiuMeng-Chang LeeChi-Tun TangGwo-Jang WuYu-Tien ChangChi-Ming ChuChia-Yang ShiauPublished in: Journal of translational medicine (2022)
In particular, cell lines showed significantly higher sensitivities to Norcyclobenzaprine and Protriptyline which were predicted to bind targets to disrupt a certain molecular function such as DNA repair, response to hormones, or DNA-templated transcription, and may lead to an effect on survival-related pathways including cell cycle arrest, response to ER stress, glucose transport, and regulation of autophagy. However, it is recommended that their mechanism of action and efficacy are further determined.
Keyphrases
- dna repair
- cell cycle arrest
- cell death
- dna damage
- pi k akt
- single molecule
- dna damage response
- signaling pathway
- circulating tumor
- oxidative stress
- transcription factor
- blood glucose
- endoplasmic reticulum stress
- type diabetes
- drug induced
- emergency department
- skeletal muscle
- free survival
- insulin resistance
- metabolic syndrome
- electronic health record