WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M.

Petra HenningSofia Movérare-SkrticAnna WesterlundPedro Paulo Chaves de SouzaThais Floriano-MarcelinoKarin H NilssonMaha El ShahawyClaes OhlssonUlf H Lerner

Published in: Journal of inflammation research (2021)

These findings demonstrate that OSM is a robust stimulator of Wnt16 mRNA in calvarial osteoblasts and that WNT16 acts as a negative feedback regulator of OSM-induced osteoclast formation in the calvarial bone cells, but not in the bone marrow.

Keyphrases

bone regeneration
cell proliferation
bone marrow
stem cells
bone loss
induced apoptosis
transcription factor
mesenchymal stem cells
high glucose
cell cycle arrest
diabetic rats
oxidative stress
endoplasmic reticulum stress
signaling pathway
body composition
stress induced
postmenopausal women