A residual connection enabled deep neural network model for optic disk and optic cup segmentation for glaucoma diagnosis.

Glaucoma diagnosis at an early stage is vital for the timely initiation of its treatment for and preventing possible vision loss. For glaucoma diagnosis, an accurate estimation of the cup-to-disk ratio (CDR) is required. The current automatic CDR computation techniques attribute lower accuracy and higher complexity, which are important considerations for diagnostics system design to be used for such critical diagnoses. The current methods involve a deeper deep learning model, comprising a large number of parameters, which results in higher system complexity and training/testing time. To address these challenges, this paper proposes a Residual Connection (non-identity)-based Deep Neural Network (RC-DNN), which is based on non-identity residual connectivity for joint optic disk (OD) and optic cup (OC) detection. The proposed model is emboldened by efficient residual connectivity, which is beneficial in several ways. First, the model is efficient and can perform simultaneous segmentation of the OC and OD. Second, the efficient residual information flow permeates the vanishing gradient problem which results in faster converges of the model. Third, feature inspiration empowers the network to perform the segmentation with only a few network layers. We performed a comprehensive performance evaluation of the developed model based on its training in RIM-ONE and DRISHTIGS databases. For OC segmentation, for the images (test set) from {DRISHTI-GS and RIM-ONE} datasets, our proposed model achieves the dice coefficient, Jaccard coefficient, sensitivity, specificity, and balanced accuracy of {92.62, 86.52}, {86.87, 77.54}, {94.21, 95.36}, {99.83, 99.639}, and {94.2, 98.9}, respectively. These experimental results indicate that the developed model provides significant performance enhancement for joint OC and OD segmentation. Additionally, the reduced computational complexity based on reduced model parameters and higher segmentation accuracy provides the additional features of efficacy, robustness, and reliability of the developed model. These attributes of the developed model advocate for its deployment of population-scale glaucoma screening programs.